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ICBS2017 scientific program

PROGRAM HIGHLIGHTS

·Keynote speakers

K. Barry Sharpless, 2001 Nobel Prize in Chemistry, The Scripps Research Institute, USA Biological applications of SuFEX click chemistry

Zixin Deng, Shanghai Jiao Tong University, Shanghai, China

Chemical Biology of S modifications

Rolf Müller,Helmholtz, Germany

Expanding antibiotic chemical space baed on bacterial biodiversity to fight antimicrobial resistance

Masatoshi Hagiwara, Kyoto University, Japan

RNA-targeting chemical therapeutics

ICBS President’s Forum to feature world thought leaders to focus on promoting chemical biology with synthetic biology

ICBS2017 presents cutting edge sciences by distinguished young chemical biologists

ICBS Young Chemical Biologists’ Forum (Oct 17, 2017)

Rising stars session by new ICBS Young Chemical Biologist awardees 2017 (competition open)

Podium Flash Presentations by selected poster presenters (1 min x >50)

Trainee travel award application open

Ten scientific sessions by more than 40 invited speakers from 14 countries

Special sessions to promote industrial interactions and global collaborations

Global chemical biology landscape – an update

Chemical biology in pharmaceutical industry


Day 1- Tuesday, October 17, 2017

ICBS Young Chemical Biologists’ Forum(YCB as ICBS Young Chemical Biologist awardee)

Chairs: Xiaoguang Lei, (ICBS YCB2013), Peking University

Qi Zhang, Fudan University


A shotgun approach to inquire degradable kinome

Li Tan, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China

XFEL for structural chemical biology of GPCRs

Haitao Zhang, Zhejiang University, China


Stimuli-responsive nucleic acids as potential sensors and drugs

Yu Xiang, Tsinghua University


Chemoproteomic Profiling Reveals the Anti-steatosis Mechanism of Traditional Chinese Medicine

Chu Wang, Peking University


Biosynthesis of PP2A inhibitor Rubratoxin A

Youcai Hu, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College


Mechanistic Studies of a Multifunctional 2-Oxoglutarate Dependent Non-heme Iron Enzyme, AsqJ

Yisong Guo, Carnegie Mellon University


Mechanistic investigation of radical S-adenosylmethionine enzymes

Qi Zhang, Fudan University


Development of far-red to near-infrared small-molecules fluorophores and their application to fluorescent probes

Kenjiro Hanaoka (YCB2014), The University of Kokyo, Japan


Small-molecule stabilization of protein-protein interactions

Christian Ottmann (YCB2013), Eindhoven University of Technology, Netherlands


Inspiration from Fluorination: Chemical Biology Approaches to Probe Molecular Recognition Events in Transcription

William Pomerantz (YCB2016), University of Minnesota Twin Cities, USA


Regulation and targeting of BAX-mediated apoptosis

Evripidis Gavathiotis (YCB2015), Albert Einstein College of Medicine


Electrophysiology, Unplugged: Using Chemistry to Watch Cells in Action

Evan Miller (YCB2015), University of California- Berkeley, USA


16:00 -

Welcome ceremony(including Group Photo)

Chair:Lixin Zhang, ECUST

Keynote opening lecture

Chemical Biology of S modifications

Zixin Deng, Shanghai Jiao Tong University, Shanghai, China


Podium flash presentations for selected posters

Chair: Tom Pfeifer, CDRD, Canada


18:00-20:00

Welcome reception


DAY 2 – Wednesday, October 18, 2017

ICBS President’s forum and Round table discussion:

Synthetic Biology to drive chemical biology and biotechnology

lSang Yup Lee,Korea Advanced Institute of Science and Technology, Korea

lJens Nielsen, Chalmers University of Technology, Sweden

lEriko Takano, University of Manchester, UK

lGeorge Guo-Qiang Chen, Tsinghua University, China

Next Generation Industrial Biotechnology based on Halophiles

lHaifeng Ye, East China Normal University, China

Engineering of Optogenetic Designer Human Cells for Diabetes Therapy


I.Chemical innovations to expand chemical space and reach the undruggables

Session 1 Expand the chemical space

Chairs: Jason Micklefield, The University of Manchester, UK

Huw Davies, Emory University, USA

Mechanistic studies of the cyclization reactions in the biosynthesis of spinosyn

Hung-wen (Ben) Liu, University of Texas at Austin, USA

Heterologous Expression of a Large-sized Natural Product Biosynthetic Gene Cluster in Streptomyces

Eung-Soo Kim, Inha University, Korea

Diversification of bioactive natural and non-natural products using engineered biosynthetic pathways and enzymes

Jason Micklefield, The University of Manchester, UK


Genetically encoding phosphotyrosine and its nonhydrolyzable analog

Feng Wang, California Institute for Biomedical Research, USA


Beyond orthogonality, another good reaction for click chemistry

Jiajia Dong, Shanghai Institute of Organic Synthesis, China


Collaborative approaches for selective C-H functionalization

Huw Davies, Emory University, USA

Session 2 Chemical biology to address undruggable targets

Chairs: Mel Reichman, Lankenau Institute for Medical Research, USA

Jiangyun Wang, Institute of Biophysics, Chinese Academy of Sciences, China

Exploring Complex Protein Structures and Protein-Protein Interactions with CXMS

Xiaoguang Lei (YCB2013), Peking University

Targeting E2/E3 ubiquitin ligase activity as a novel strategy to combat autoimmunity

Kamyar Hadian, Helmholz-Zentrum munchen, Germany


Metalloprotein design using genetic code expansion

Jiangyun Wang, Institute of Biophysics, Chinese Academy of Sciences, China


Therapeutic strategies to target tumor suppressors through protein interaction network

Andrei Ivanov, Emory University, USA

Day 3- Thursday, October 19, 2017

II. Addressing challenges in diseases with chemical biology

Session 3 Determine molecular mechanisms of an active compound

Chair: Bridget Wagner, Broad Institute of MIT and Harvard, USA

Seung Bum Park, Seoul National University, Korea


Systematic approaches to small-molecule mechanism-of-action studies

Bridget Wagner, Broad Institute of MIT and Harvard, USA ,


Exploration of bioactive compounds, target identification and development of the new analytical methods

Hiroyuki Osada, RIKEN, Japan


FITGE-based Target Identification: New Tool in Chemical Biology

Seung Bum Park, Seoul National University, Korea


Resistance Mechanisms to mTOR Kinase Inhibitors in Cancer

X.F. Steven Zheng, Rutgers Cancer Institute of New Jersey, USA


Session 4 Interrogate diseases with chemical biology I

Chairs: Guo-Qiang Chen, Shanghai Jiaotong University, China

Siddhartha Roy, Boss Institute, India

Cancer cell fate determination-based chemical biology investigation

GuoQiang Chen, Shanghai Jiaotong University, China


A general methodology for conversion of life-threatening viruses into live virus vaccines

Demin Zhou, Peking University, China


Design and development of slycosyltransferase inhibitors as novel anti-metastatic agents

Danielle Skropeta, University of Wollongong, Australia


Discovery of first-in-class specific small molecules antagonizing PXR(NR112) to overcome drug resistance in human cancers

Taosheng Chen, St Jude Children’s Research Hospital, USA


Novel small molecule MerTK inhibitors and their dual function in cancer treatment

Xiaodong Wang, The University of North Carolina at Chapel Hill, USA


Aglycone polyethersJ1-001 and itshomologues are effective tobroad cancer cells

Tiangang Liu, Wuhan University, China


Session 5: Interrogate diseases with chemical biology II

Chairs: Hanne Ingmer,University of Copenhagen,Denmark

Cong Liu, Shanghai Institute of Organic Chemistry, China


Natural quorum quenching compounds targeting Staphylococcus aureus quorum sensing- implications for colonization and infection

Hanne Ingmer, University of Copenhagen, Denmark


Selective labelling and eradication of antibiotic-tolerant populations in bacterial biofilms

Liang Yang, Nanyang Technological University, Singapore


Interplay between a-synuclein and lipids in Parkinson’s disease

Cong Liu, Shanghai Institute of Organic Chemistry, China


Novel mechanism of action of an anti-biofilm antibiotic

Chengzhang Fu, Helmholz-Zentrum ur infektionsforschung GmbHf, Germany

Protein Aggregation Small Molecule Inhibitor Discovery and Mechanisms

Bin Xu, Center for Drug Discovery, and School of Neuroscience, Virginia Tech, USA


Session 6 Computational approaches to accelerate chemical biology research

Chairs: Luhua Lai, Peking University China

Petr Bartunek, Institute of Molecular Genetics, Czech Republic

Chemical and biological space exploration

Petr Bartunek, Institute of Molecular Genetics, Czech Republic


Structural Insights of Electron Transfer in P450 Monooxygenase

Jiahai Zhou, Shanghai Institute of Organic Chemistry, China


Rational Design of Protein Allosteric Regulators

Luhua Lai, Peking University China


Evolution of chemical similarity: from structure to activity

Paul A. Clemons, Broad Institute of MIT and Harvard, USA


Day 4 – Friday, October 20, 2017


III. Chemical biology innovations and applications

Session 7 Molecular biosensors and actuators

Chair: Jin Zhang, University of California San Diego, USA


NIR Fluorescent Organic Nanoprobes

Weihong Zhu, East China University of Science and Technology, China


Making gels in cells: total synthesis of stress granules by multivalent enhancers

Takanari Inoue, Johns Hopkins University, USA


Protein engineering and the development of intracellular biosensors

Robert Campbell, University of Alberta, Canada


Genetically encoded fluorescent sensors reveal dynamic regulation of redox metabolism in living cells

Yi Yang, East China University of Science and Technology, China


Session 8 Biological insights with chemical biology

Chair: Tapas Kundu, JCASR, India

Jonathan Baell, Monash University, Australia


Protein degradation based conditional knockout

PinghuaLiu, Boston University, USA


Crosstalk between epigenetic systems in bacteria

Shi Chen, Wuhan University, China


Chemical-assisted sequencing of epigenetic nucleic acid modifications

Chengqi Yi, Peking University, China


Chemical intervention of RNA methylation

Caiguang Yang, Shanghai Institute of Material Medica, China


Session 9 New chemical modalities

Chairs: Xiyun Yan, Institute of Biological Physics, Chinese Academy of Sciences, China

Zhen Xi, Nankai University, China


Nanozyme: Discoveryand itsApplications in Medicine

Xiyun Yan, Institute of Biological Physics, Chinese Academy of Sciences, China

Chemoenzymatic glycan labeling: methods and applications

Peng Wu, John Hopkins University, USA

MetDNA: Recursive Metabolite Annotation and Dysregulated Network Analysis for Untargeted Metabolomics

Zhengjiang Zhu, Shanghai Institute of Organic Chemistry, China

Spatiotemporal Control Cellular Functions by Environment Stimuli-Induced Proximity

Wei Wang, East China University of Science and Technology, China

Session 10, Emerging technologies

Chairs: Mikiko Sodeoka, RIKEN, Japan

Peng Chen, Peking University, China

Bioorthogonal cleavage reactions in living cells

Peng Chen, Peking University, China

Perturbation of microtubule function using designed peptides

Surajit Ghosh, CSIR-IICB, India

Smashing and Stapling: Chemical control of protein function through regulated polypeptide cleavage

Michael Lin, Stanford University, USA

Ribosome pausing at AT-rich codons regulates translation in Streptomyces tsukubaensis

Byung-Kwan Cho, Korea Advanced Institute of Science and Technology (KAIST), Republic of Korea

Turn-on fluorescent labeling using O-NBD unit

Mikiko Sodeoka, RIKEN, Japan

Closing keynote lecture

K. Barry Sharpless, 2001 Nobel Prize in Chemistry, The Scripps Research Institute, La Jolla, USA

“Biological applications of SuFEX click chemistry”

Evening

Closing ceremony, dinner, and performance

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Special sessions:

Rising stars in chemical biology: ICBS Young Chemical Biologist awards 2017

Presentations by awardees of ICBS YCB2017

Chemical biology in pharmaceutical industry

Chair: Christian Ottmann, Eindhoven University of Technology, Netherlands

Panelists: Yves Auberson, Novartis, Switzerland

Rathnam Chaguturu, iDDPartners, USA

Hong Shen, Roche Innovation Center, China

Global chemical biology landscape – an update

Chair: Masatoshi Hagiwara, University of Kyoto, Japan

The Japanese Society for Chemical Biology

Masatoshi Hagiwara, University of Kyoto, Japan

Chemical biology initiatives in China

Lihe Zhang, Peking University, China

Graduate Chemical Biology education in the US

Zaneta Nikolovska-Coleska, University of Michigan, USA

EU-OpenScreen and chemical biology in Europe

Bahne Stechmann, EU-OPENSCREEN, Berlin, Germany

Updates on chemical biology societies and activities around the globe

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email: icbs2017@chemical-biology.org
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